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. Author manuscript; available in PMC: 2022 Aug 25.
Published in final edited form as: J Am Chem Soc. 2021 Aug 13;143(33):13044–13055. doi: 10.1021/jacs.1c02248

Figure 6.

Figure 6.

RIBOTAC 4 inhibits invasion of TNBC cells with reprogrammed selectivity in vivo. (A) In vivo treatment of 4 (56 mg/kg, q.o.d., 30 days) decreased the number of lung nodules (white nodules) stained with Bouin’s solution (n = 11 for vehicle or 4). (B) Lung tissue treated with RIBOTAC 4 exhibited decreased miR-21 levels and unchanged pERK levels, while 1 exhibited decreased pERK levels and unchanged miR-21 levels (n = 3). *p < 0.05, as determined by a two-tailed Student’s t test. All images are from biological replicates.