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. 2022 Jul 6;136(13):1053–1069. doi: 10.1042/CS20220082

Figure 2. L-Gln inhibits IL-1β-induced cyclooxgenease-2 (COX-2), induced nitric oxide synthase (iNOS), and matrix metalloproteinase-13 (MMP-13) expression, and NO, prostaglandin E-2 (PEG-2), and tumour necrosis factor (TNF)-α release in rat osteoarthritis (OA) chondrocytes.

Figure 2

(A) Nitrite evaluated using the Griess test. (B,C) The levels of PGE-2 and TNF-α as determined by enzyme-linked immunosorbent assay. (D–F) The mRNA levels of iNOS, COX-2, and MMP-13. (G–L) The protein levels of iNOS, COX-2, and MMP-13. (M,N) MMP-13 as determined by immunofluorescence and analyzed with Image-Pro6.0; scale bar = 50μm. #P<0.05 versus the control group. *P<0.05, **P<0.01 versus the IL-1β group; n=3.