Table VII.
Predicted risk of BPD or death, including deceased patients
Characteristics | Risk of BPD* (n = 439) | P value |
---|---|---|
VEGF | 0.98 ± 0.10 [0.80–1.20] | .83 |
IL-6 | 1.71 ± 0.26 [1.27–2.30] | <.001 |
IL-8 | 1.71 ± 0.41 [1.06–2.74] | .027 |
IL-10 | 1.14 ± 0.17 [0.86–1.53] | .36 |
Values are OR ± SE [95% CI].
This analysis was performed to assess for bias from excluding the 28 deceased patients as was done in Table V. Ordered logistic regression with independent variable of biomarker (mean log-transformed levels from days 0 to 7 of life) and dependent categorical variable of BPD severity (0 = no BPD; 1 = mild BPD; 2 = moderate BPD; 3 = BPD) adjusted for gestational age, intrauterine growth restriction, birthweight, RDS, and prenatal steroids. For a 10-fold increase in biomarker level, the odds of severe BPD vs all other categories of BPD is the aOR; likewise, the same OR reflects the risk of the combined mild, moderate, and severe BPD (any BPD) vs no BPD. patients who were deceased before 36 weeks PMA were arbitrarily coded as having severe BPD.