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. 2022 Jun 27;13(13):1992–2005. doi: 10.1021/acschemneuro.2c00222

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© 2022 The Authors. Published by American Chemical Society

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Mapping of peptides derived from CHGA and VGF in synaptosomes from AD compared to control brain cortex. (a) CHGA-derived neuropeptides. Peptide mapping shows the neuropeptides derived from the CHGA proneuropeptide. (b) VGF-derived neuropeptides. Peptide mapping shows the neuropeptides derived from the VGF proneuropeptide. For panels (a,b), the color-coded peptides indicate those present in only AD (red), present in only the control (blue), and shared by both AD and control synaptosomes (purple).