Figure 4.
Biological annotation of the two transdiagnostic latent genetic factors
(A) Manhattan plots for local genetic correlation, covariance, and variance for F1 and F2. Black bars indicate significant local genetic correlation.
(B) Scatterplot of gene set enrichment results illustrating convergence and divergence across the latent genetic factors with accompanying histograms for the top 10 gene sets for each factor.
(C) Scatterplot of neuroimaging genetic-correlation results with accompanying figures where the −log10 p values are mapped across the cortex, as parcellated in the Desikan-Killiany-Tourville atlas.
(D) Smoothed line plots of gene set expression across developmental time in the PsychENCODE dataset for prioritized genes with transcriptomic profiles that are spatially similar to the neuroimaging genetic correlation maps for F1 and F2 (as indexed in the Allen Human Brain Atlas). For all plots, the dashed black line corresponds to the Bonferroni-corrected significance threshold when applicable.