Table 1.
Summary of study phenotypes
| GWAS (abbr.) | Source | N | h2 | λGC | Mean χ2 | Intercept | Ratio |
|---|---|---|---|---|---|---|---|
| Depressive symptoms (DEP) | present study | 252,252 | 0.08 | 1.31 | 1.38 | 1.01 | 0.02 |
| Manic symptoms (MAN) | present study | 252,252 | 0.08 | 1.31 | 1.39 | 1.00 | 0.00 |
| Psychotic symptoms (PSY) | present study | 252,252 | 0.07 | 1.31 | 1.33 | 1.00 | 0.01 |
| Major depressive D/O (MDD) | Wray et al., 20185 | 138,884 | 0.10 | 1.19 | 1.20 | 1.00 | <0 |
| Bipolar II D/O (BD2) | Stahl et al., 20194 | 25,576 | 0.10 | 1.07 | 1.08 | 1.03 | 0.42 |
| Bipolar I D/O (BD1) | Stahl et al., 20194 | 45,871 | 0.22 | 1.31 | 1.37 | 1.04 | 0.09 |
| Schizoaffective D/O (SZA) | Stahl et al., 20194 | 9,667 | 0.27 | 1.06 | 1.06 | 1.02 | 0.35 |
| Schizophrenia (SCZ) | Ruderfer et al., 201821 | 65,967 | 0.23 | 1.49 | 1.63 | 1.05 | 0.08 |
| F1 (mood disturbance) | present study | 377,518 | N/A | 1.44 | 1.53 | 1.05 | 0.10 |
| F2 (serious mental illness) | present study | 51,276 | N/A | 1.46 | 1.61 | 1.02 | 0.04 |
Heritability (h2) was estimated using LD score regression. λGC refers to the median χ2 statistic of the GWAS divided by the expected median of the χ2 distribution with 1 degree of freedom. Mean χ2 refers to the average χ2 statistic of the GWAS. Intercept refers to the estimated intercept from univariate LD score regression. Ratio refers to a measure of stratification bias that is defined as (Intercept – 1)/(Mean χ2 − 1). To harmonize measurement approaches among psychiatric disorders, summary statistics for MDD were obtained for the clinically ascertained cohorts, excluding 23andMe and UK Biobank. D/O, disorder; The effective sample size is reported for F1 and F2 (STAR Methods).