Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Simulated kinetics of (A) Dibenzo[def,p]chrysene (DBC) and (B) DBC-11,12-diol in mouse (dashed line) and human (solid line) physiologically based pharmacokinetic (PBPK) model for an oral bolus dose of 1 mg/kg-body weight in mouse and the corresponding human equivalent dose of 0.2419 mg/kg-body weight. Predictions for the disposition of (DBC) after 72 hours of oral administration estimated from the (C) human and (D) mouse model.
