. Author manuscript; available in PMC: 2022 Jul 8.

Published in final edited form as: Toxicol Appl Pharmacol. 2021 Dec 18;438:115830. doi: 10.1016/j.taap.2021.115830

Table 8:

Metabolism parameters for mice and humans used in PBPK model

Substrate	Species	Best Fit Model	Cl_int (mL/min/mg)	V_max (nmol/min/mg)	K_m (μM)
DBC^†	Mouse	MM		19.38	6.63
DBC^†	Human	MM		0.27	0.915
DBC-Diol^* (Phase I)	Mouse	First Order	11.58
DBC-Diol^* (Phase I)	Human	First Order	0.54
DBC-Diol^* (Phase II)	Mouse	MM		26.49	29.7
DBC-Diol^* (Phase II)	Human	MM		7.74	25.9

^†

Ref (31)

Ref (33)