Table 4.

Univariate and multivariate analysis of characteristics associated with overall survival

Variables	Univariate analysis				Multivariate analysis
	Hazard Ratio	95%CI		P-value	Hazard Ratio	95%CI		P-value
Age	1.041	0.764	1.418	0.798
Sex	0.889	0.653	1.212	0.458
T stage	0.573	0.43	0.764	< 0.001	0.719	0.533	0.969	0.03
N stage	0.526	0.401	0.69	< 0.001
M stage	0.385	0.143	1.037	0.059
TNM stage	0.509	0.388	0.667	< 0.001	0.657	0.49	0.881	< 0.001
Histological grade	0.724	0.537	0.976	0.034
PRDM5	2.986	2.084	4.278	< 0.001	2.626	1.824	3.781	< 0.001
Vascular invasion	0.497	0.359	0.688	< 0.001	0.694	0.493	0.976	0.036
Nerve invasion	0.643	0.429	0.964	0.033