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. 2022 Jul 7;20:102. doi: 10.1186/s12964-022-00911-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Receptor-mediated PI3K pathway at CDRs in Hep3B cells. A Representative confocal images of actin-SH3YL1 showing SH3YL1 is localized at CDRs (enlarge images). (B Representative confocal images of actin and GFP-BtkPH. GFP-BtkPH was expressed in Hep3B cells as a probe protein to identify PIP3. Confocal images showed recruitment of GFP-BtkPH to CDRs, indicating that PIP3 was generated at the structures. C and D Representative confocal images of actin-p110α (C) and actin p110β (D) showing p110 isoforms are localized at CDRs (enlarge images). E Representative confocal images of EGF receptor and insulin receptor. Both receptors are localized at CDRs in Hep3B (enlarge images)