Table 3.

Therapeutic options in MPSs

Pharmacological management
Source	Publication date	Drug admnistered
Clarke et al. [27]	2009	Laronidase (ERT)
Burton e al. [28]	2015	Elosulfase alpha (ERT)
Robinson et al. [29]	2002	Pamidronate (biphosphonate)
Polgreen et al. [30]	2017	Adalimumab (TNF alpha inibitor)
Congedi et al. [31]	2018	NSAIDs, Acetaminophen, Opioids
Politei et al. [32]	2016	ERT, NSAIDs, Acetaminophen, Opioids
Felleiter et al. [33]	2005	NSAIDs, Acetaminophen, Opioids
Mozolewski et al. [34]	2017	Indomethacin plus Isoflavonoid
Hauer et al. [35]	2007	Anesthetics, Tryciclic Antidepressants, Anticonvulsivants
Hauer et al. [36]	2010	Anesthetics, Tryciclic Antidepressants, Anticonvulsivants
Harrison et al. [37]	2017	Marijuana (Cannabinoids)

Rehabilitation management
Source	Publication date	Rehabilitation therapies
Mishra et al. [48]	2017	Spinal Orthosis
Ravindran et al. [49]	2013	Complementary and Alternative medicine (CAM)
Vance et al. [50]	2014	Transcutaneous Electrical Nerve Stimulations (TENS)
Zhao et al. [51]	2008	Acupunture and Acupressure
Fisher et al. [52]	2018	Psychological Therapy
Winston et al. [53]	2005	Mindfullness, Excercises, Hypnosis, Educational programs, Biofeedback
Braun et al. [54]	2009	Animal-assisted therapy (AAT)
Kenny et al. [55]		Music therapy

Pharmacological/rehabilitation combined management
Source	Publication date	Treatments
Congedi et al. [31]	2018	ERT, NSAIDs, Opioids, Cannabinoids, Physical/Psychological interventions