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. 2022 Jul 7;20:319. doi: 10.1186/s12951-022-01487-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Characterization of lipid-coated albumin nanoparticles (LANP) and detection of siRNA-loaded LANP transfection efficiency. a The average size of albumin-PTX, lipid-coated albumin nanoparticles with PTX (LANP-PTX) and with PTX/SRI-siRNA (LANP-PTX-siSRI) was detected. b The Zeta potential of albumin-PTX, LANP-PTX, and LANP-PTX-siSRI was measured. c The particle size distribution of albumin-PTX and LANP-PTX-siSRI was analyzed. d–e LANP-PTX was photographed by the TEM. f The release of siRNA from LANP-PTX-siSRI into saline was measured. g Migration of blank LANP, Fam-labeled siRNA (Fam-siRNA), and LANP with Fam-labeled siRNA (LANP-Fam-siRNA) in agarose gel electrophoresis. h–i The Fam signals in A2780/PTX and A549/PTX were detected by flow cytometry. j The intracellular distribution of LANP-Fam-siRNA was detected by laser confocal microscopy. Scale bar, 25 μm