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. 2022 Jul 7;20:319. doi: 10.1186/s12951-022-01487-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Suppression of PTX-resistant tumor growth by LANP-PTX-siSRI in vivo. a In vivo fluorescence imaging of Cy5.5 fluorescent-labeled LANP-PTX-siSRI (LANP-Cy5.5) at 30 min, 1.5 h, and 5 h after intravenous injection. Red arrows indicate the locations of tumors. b Ex vivo biodistributions of LANP-Cy5.5 at 5 h after intravenous injection. The column shows the intensity of ex vivo fluorescence and the major organs and the tumor were imaged. T, H, Li, Sp, Lu, and Ki stand for tumor, heart, liver, spleen, lung, and kidney, respectively. c Measurement of tumor volume during normal saline, albumin-PTX, and LANP-PTX-siSRI treatment. d Measurement of tumor weight in saline control, albumin-PTX, and LANP-PTX-siSRI groups after treatment. e Images of xenograft tumor after the sacrifice of mice. f Measurement of body weight in saline control, albumin-PTX, and LANP-PTX-siSRI groups during treatment. g Expression of SRI mRNA in tumor tissue of various groups after treatment determined by qRT-PCR. h Expression of SRI protein in tumor tissue of various groups after treatment detected by Western blot. i H&E, PCNA, and TUNEL stained tumor slices from various groups. Scale bar, 20 μm; *P < 0.05; **P < 0.01