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. 2022 Jul 7;20:319. doi: 10.1186/s12951-022-01487-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Effect of TGF-β signaling and LANP-PTX-siSRI in reversal cancer chemoresistance. a Expression of Smad2 and P-Smad2 in chemoresistant A2780/PTX and A549/PTX cells was detected by Western blot. b–c Expression of SRI protein in A2780/PTX and A549/PTX after TGF-β administration was detected by Western blot. d–e Expression of SRI mRNA after TGF-β administration was detected by qRT-PCR. f The concentration of calcium ions in A2780/PTX and A549/PTX after TGF-β administration was detected by flow cytometry. g–h Fluorescence intensity reflected calcium ion concentration in A2780/PTX (g) and A549/PTX (h) after TGF-β administration was detected by flow cytometry. i Schematic illustration of LANP-PTX-siSRI in reversal cancer chemoresistance