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. 2022 Jul 8;240:114596. doi: 10.1016/j.ejmech.2022.114596

Fig. 2.

Fig. 2

Inhibition curves of MPI29-47 and PF-07321332 on MPro. Triplicate experiments were performed for each compound. For all experiments, 20 nM MPro was incubated with an inhibitor for 30 min before 10 μM Sub3 was added. The MPro-catalyzed Sub3 hydrolysis rate was determined by measuring linear increase of product fluorescence (Ex: 336 nm/Em: 455 nm) at the initial 5 min reaction time.