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. 2022 Jun 28;14(13):3168. doi: 10.3390/cancers14133168

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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In vivo functionality of UCB CAR-T. (A) The experimental protocols. (B) Overall survival of mice treated with fresh UCB CAR-T, and the control group (C0), over time (n = 5 mice per group, dose: 10 × 10⁶ T cells). (C) Bioluminescent intensity of the mice treated with UCB CAR-T and the control groups (n = 5 mice per group). Black cross indicates dead mice. (D) Percentage of different T cell subsets (T_SCM + T_CM and T_EM + T_EMRA) for UCB CAR-T (TCD4 and TCD8), for each group, over time. UCB: Umbilical Cord Blood.