Table 2.
Characteristics of the ICU stay for septic shock according to cancer status.
| All Stays N = 239 |
Stays of Non-Cancer Patients n = 91 |
Stays of Cancer Patients n = 148 |
p Value | |
|---|---|---|---|---|
| Treatments before ICU admission | ||||
| Fluid therapy | 178 (76.1) | 67 (74.4) | 111 (77.1) | 0.65 |
| Norepinephrine | 80 (33.9) | 32 (35.2) | 48 (33.1) | 0.74 |
| Site of infection | ||||
| Respiratory tract | 104 (43.5) | 42 (46.2) | 62 (41.9) | 0.52 |
| Urinary tract | 58 (24.3) | 25 (27.5) | 33 (22.3) | 0.36 |
| Gastrointestinal tract | 75 (31.4) | 28 (30.8) | 47 (31.8) | 0.87 |
| Skin and soft tissue | 27 (11.3) | 18 (19.8) | 9 (6.1) | <0.01 * |
| CRBSI | 19 (8.0) | 3 (3.3) | 16 (10.8) | 0.04 * |
| Central nervous system | 1 (0.4) | 1 (1.1) | 0 (0.0) | 0.76 |
| Osteoarticular system | 7 (2.9) | 6 (6.6) | 1 (0.7) | 0.03 * |
| Other sites | 10 (4.2) | 7 (7.7) | 3 (2.0) | 0.08 |
| Unknown site | 23 (9.6) | 3 (3.3) | 20 (13.5) | <0.01 * |
| Laboratory findings # | ||||
| Creatinine (μmol/L) | 130.0 [87.1–192.7] | 134.0 [92.0–236.0] | 118.0 [83.4–172.3] | 0.03 * |
| CRP (mg/L) | 166.5 [92.7–249.5] | 172.5 [99.1–249.1] | 163.0 [84.0–249.3] | 0.42 |
| Lactate (mmol/L) | 2.6 [1.7–4.1] | 2.7 [1.8–4.1] | 2.4 [1.6–4.2] | 0.98 |
| Hemoglobin (g/dL) | 9.6 [8.2–11.0] | 10.5 [8.9–12.3] | 9.1 [7.8–10.2] | <0.01 * |
| WBC count (109/L) | 14.1 [9.1–22.3] | 16.4 [11.5–23.1] | 12.3 [5.3–21.6] | <0.01 * |
| Neutrophil count (109/L) | 11.7 [6.6–19.0] | 14.0 [10.1–20.2] | 9.5 [3.8–18.4] | <0.01 * |
| Platelet count (109/L) | 133.0 [63.0–235.0] | 177.0 [110.5–270.5] | 105.0 [34.0–211.5] | <0.01 * |
| ICU stay | ||||
| SAPS II | 51.0 [42.0–68.0] | 50.0 [43.5–65.5] | 55.5 [41.8–68.0] | 0.44 |
| Duration of ATB therapy (days) | 5.0 [3.0–10.5] | 6.0 [3.0–11.0] | 5.0 [2.0–10.3] | 0.25 |
| Antifungal therapy | 121 (50.6) | 33 (36.3) | 88 (59.5) | <0.01 * |
| Catecholamines | 226 (94.6) | 87 (95.6) | 139 (93.9) | 0.81 |
| Renal replacement therapy | 70 (29.3) | 33 (36.3) | 37 (25.0) | 0.06 |
| NIV | 55 (23.0) | 26 (28.6) | 29 (19.6) | 0.11 |
| Mechanical ventilation | 143 (59.8) | 60 (65.9) | 83 (56.1) | 0.13 |
| Duration of MV (days) | 5.0 [2.0–11.0] | 6.0 [2.8–15.5] | 5.0 [2.0–10.5] | 0.38 |
| DIC | 44 (18.6) | 18 (20.0) | 26 (17.8) | 0.67 |
| MODS | 79 (33.1) | 36 (39.6) | 43 (29.1) | 0.09 |
| ARDS | 26 (10.9) | 9 (9.9) | 17 (11.5) | 0.70 |
| Transfusions | 152 (63.6) | 45 (49.5) | 107 (72.3) | <0.01 * |
| Red blood cells | 143 (59.8) | 43 (47.3) | 100 (67.6) | <0.01 * |
| Fresh frozen plasma | 51 (21.3) | 18 (19.8) | 33 (22.3) | 0.64 |
| Platelet concentrates | 87 (36.4) | 18 (19.8) | 69 (46.6) | <0.01 * |
| Advance directives | 13 (5.4) | 6 (6.6) | 7 (4.7) | 0.73 |
| LTE in the ICU | 47 (19.7) | 18 (19.8) | 29 (19.6) | 0.97 |
| Outcome | ||||
| ICU LOS (days) | 5.0 [3.0–13.0] | 6.0 [3.0–15.0] | 5.0 [2.0–11.3] | 0.27 |
| Total LOS (days) | 24.0 [12.0–42.0] | 19.5 [10.8–41.0] | 25.5 [13.8–42.0] | 0.33 |
| Mortality | ||||
| At d28 | 65 (27.3) | 27 (29.7) | 38 (25.9) | 0.52 |
| In the ICU | 72 (30.3) | 27 (30.0) | 45 (30.4) | 0.95 |
| In hospital | 91 (39.2) | 32 (35.6) | 59 (41.6) | 0.36 |
Footnotes: Data are all expressed in median IQR [25–75] or n/N (%) where n/N is the total number of patients with available data. # Blood tests on ICU admission. * p < 0.05. Abbreviations: ARDS, acute respiratory distress syndrome; ATB, antibiotics; CRBSI, catheter-related bloodstream infection; CRP, C-reactive protein; d28, day 28 of hospitalization; DIC, disseminated intravascular coagulation; ICU, intensive care unit; LOS, length of stay; LTE, limitation of therapeutic effort; MODS, multiple organ dysfunction syndrome; MV, mechanical ventilation; NIV, non-invasive ventilation; SAPS II, simplified acute physiology score II; SSh, septic shock; WBC, white blood cells.