Table 3.
Summary of the overall results.
| Compound | Recombinant hGAPDH Activity |
Intracellular GAPDH Activity | L-Lactate Secretion | Cell Proliferation | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Fibroblast | PANC-1 | MIA PaCa-2 | PANC-1 | MIA PaCa-2 | Fibroblast | PANC-1 | MIA PaCa-2 | ||||
| P | CSCs | P | CSCs | ||||||||
| AXP-1007 | = | = | = | = | nd | nd | = | = | nd | = | nd |
| AXP-3009 |
|
= |
|
|
|
|
|
|
nd |
|
nd |
| AXP-3018 |
|
= | = | = | = | = | = | = |
|
= |
|
| AXP-3019 |
|
= |
|
|
|
|
= |
|
|
|
|
“P”, parental cells; “CSCs”, cancer stem cells; “nd”, not done; inhibition; = no significance difference.