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. 2022 Jun 30;14(13):3218. doi: 10.3390/cancers14133218

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A 48-year-old female with ureteral NENs. (A) Coronal T2 nonfat sat image shows a large expansible hematoma in the ureteric stump (arrows). (B) Coronal T1 postcontrast delayed fat sat image: Shows a large expansible hematoma with intrinsic high T1 signal. (C) Axial T1 postcontrast delayed fat sat subtraction image: a small enhancing nodule (arrows) along the superior aspect of the stump. (D) Left lower ureter mass consists of a segment of the ureter with an attached firm, tan-brown, irregular, mass, measuring 11.5 × 7.0 × 6.0 cm. (E) E&H staining: 20× shows polypoid tumor bulging into the ureter lumen. Normal urothelial mucosa and muscle layer can be seen on the top half (arrow). (F) H&E straining: 200× high-power view shows tumor cells arranged in a trabecular and tubular pattern. (G) Synaptophysin staining: 200× shows tumor cells expressing synaptophysin (brown staining), which is a marker of neuroendocrine differentiation.