Table 1.

The miRNA-regulating activity levels in in vitro studies depending on the different enoxacin concentrations.

miRNA	Conc. [µM]	Effect	Expression Change	Cell Line	Ref.
		[↑/↓]	Change-Fold
Cancer cells
let-7b-5p, miR-146a-5p, miR-689	50	↓	0.5–1	4T1 (miRNA from EV),	[49]
miR-100	124	↓	0.5–1	primary ESFT spheres	[37]
miR-141, miR-191	124	↓	1.5–2	DU145, LNcap,	[38]
miR-21-5p, miR-30a-3p, miR-30a-5p, miR-100-5p, miR-204-5p, miR-221-3p	124	↑	<1.5	Cal62, STA-ET-8.2, TPC1	[39]
Let-7f, miR-26a,	124	↑	<1.5	A673, SW1736	[37]
miR-21	100	↑	1.5–2	MCF7	[41]
miR-16, miR-18a*, miR-21, miR-26a, miR-29b, miR-29c, miR-31, miR-193a,	124	↑	1.5–2	HCT-116	[36]
let-7f, miR-26a, miR-99a, miR-100, miR-143, miR-145,	124	↑	1.5–2	A673, STA-ET-8.2, TC252, primary ESFT spheres	[37]
miR-21-5p, miR-30a-3p, miR-100-5p, miR-146b-5p, miR-221-3p,	124	↑	1.5–2	Cal62, SW1736, TPC1	[39]
miR-17 *, miR29b, miR-132, miR-146a, miR-191 miR-449a,	124	↑	1.5–2	DU145 LNcap,	[38]
miR-214-3p	50	↑	2–2.5	4T1 (cytosolic miRNA),	[49]
miR-145	100	↑	2–2.5	MCF7	[41]
miR-7, miR-16, miR-18a*, miR-29c, miR-101, miR-128, miR-181a, miR-212	124	↑	2–2.5	HCT-116, RKO	[36]
miR-100-5p, miR-146b-5p	124	↑	2–2.5	SW1736, TPC1	[39]
miR-34a, miR-449a	124	↑	2–2.5	DU145, LNcap	[38]
let-7f, miR-99a, miR-100, miR-145	124	↑	2–2.5	A673, STA-ET-8.2, TC252, primary ESFT spheres	[37]
miR-7, miR-26a, miR-29b, miR-30a, miR-101, miR-122, miR-125a, miR-125b, miR-126, miR-128, miR-143, miR-181b, miR-205	124	↑	2.5–3	HCT-116, RKO	[36]
miR-100, miR-145	124	↑	2.5–3	A673, TC252	[37]
miR-29b	124	↑	2.5–3	LNcap	[38]
let-7a, let-7b, miR-30a, miR-31, miR-126, miR-181b, miR-193a, miR-193b,	124	↑	3–3.5	HCT-116, RKO	[36]
let-7f, miR-143, miR-181a,	124	↑	3–3.5	A673, STA-ET-8.2, primary ESFT spheres	[37]
miR-181a, miR-193b	124	↑	3.5–4	HCT-116	[36]
let-7b, miR-143, miR-205	124	↑	4–4.5	HCT-116, RKO	[36]
miR-143	124	↑	4–4.5	TC252	[37]
miR-125a	124	↑	ca. 5	HCT-116	[36]
miR-214-3p	50	↑	ca. 22	4T1 (miRNA from EV)	[49]
Non-cancer cells
miR-128-1	60	↓	0.5–1	dnTGFβRII T cells	[65]
let-7i, miR-128	50	↓	1.5–2	HEK293	[35]
let-7b, miR-23a, miR-30e, miR-96, miR-99a, miR-125a, miR-146, miR-190, miR-199a*,	50	↑	1.5–2	HEK293	[35]
miR-124a, miR-139, miR-152, miR-199b	50	↑	2–2.5	HEK293	[35]
miR-29b-1, miR-145a-5p, miR-326-3p	60	↑	2–2.5	dnTGFβRII T cells	[65]
miR-181a	60	↑	2.5–3	dnTGFβRII T cells	[65]
miR-346-5	60	↑	3–3.5	dnTGFβRII T cells	[65]

Dominant negative TGF-β receptor (dnTGFβRII). Please note that “*” is not a footnote indicator, but an essential part of the name of the specific miRNA. More information regarding the miRNAs’ nomenclature can be found in miRBase [68].