Table 2.

The miRNA regulating activity levels in in vivo studies depending on the different enoxacin concentrations.

miRNA	Dose	Effect	Expression Change:	Tissue	Ref.
		[↑/↓]	Change-Fold
miR-124	10 mg/kg 25 mg/kg	↑	ca. 4. ca. 6	rat frontal cortex	[66]
let-7a, miR-125a-5p	10 mg/kg 25 mg/kg	↑	ca. 11. ca. 20
miR-132	10 mg/kg 25 mg/kg	↑	ca. 19 (for both doses)
miR-30a-5p, miR-146b-5	15 mg/kg	↑	1.5–2	human orthotopic thyroid tumor from Cal62-luc mouse	[39]
mIR-100-5p, miR-30-3p, miR-204-5	15 mg/kg	↑	2–2.5	human orthotopic thyroid tumor from Cal62-luc mouse	[39]
miR-16, miR-18a*, miR-21, miR-26a, miR-29b, miR-29c, miR-31, miR-101, miR-193a	10 mg/kg	↑	1.5–2	tumor from HCT-116 mouse xenograft	[36]
miR-16, miR-29c, miR-31, miR-101, miR-181a	10 mg/kg	↑	1.5–2	tumor from RKO mouse xenograft	[36]
miR-128, miR-212	10 mg/kg	↑	2–2.5	tumor from HCT-116 mouse xenograft	[36]
miR-18a*, miR-21, miR-26a, miR-29b, miR-30a, miR-128	10 mg/kg	↑	2–2.5	tumor from RKO mouse xenograft	[36]
let-7b, miR-7, miR-143, miR-181b, miR-125b	10 mg/kg	↑	2.5–3	tumor from HCT-116 mouse xenograft	[36]
let-7a, miR-7, miR-122, miR-125a, miR-125b, miR-126, miR-181b, miR-193a, miR-193b, miR-205, miR-212	10 mg/kg	↑	2.5–3	tumor from RKO mouse xenograft	[36]
let-7a, miR-30a, miR-122, miR-126	10 mg/kg	↑	3–3.5	tumor from HCT-116 mouse xenograft	[36]
miR-143	10 mg/kg	↑	3–3.5	tumor from RKO mouse xenograft	[36]
miR-125a, miR-181a, miR-193b	10 mg/kg	↑	3.5–4	tumor from HCT-116 mouse xenograft	[36]
let-7b	10 mg/kg	↑	4.5–5	tumor from RKO mouse xenograft	[36]
miR-205	10 mg/kg	↑	4.5–5	tumor from HCT-116 mouse xenograft	[36]