Table 4.
Phototoxic effects of enoxacin depending on the UVA irradiation dose in in vitro studies.
| Effect | UVA Irradiation Dose [J/cm2] | Conc. [μM] | Cell Line | Ref. |
|---|---|---|---|---|
| Photosynthetization | 3; 6 | 62 | The THP-1 cells from tumoral monocytes | [92] |
| Phototoxicity | 4.3 | 4.5 | HeLa | [93] |
| Photohemolysis | 20 | 3.1; 31; 312 | Sheep red blood cells | [93] |
| DNA strand breaking | 1.6 | 3.1; 31; 312 | pUC18 plasmid was | [93] |
| apoptosis | 4 | 100 | HaCaT | [97] |
| Increased protoporphyrin accumulation and photosensitivity | 0.54 0.54 |
156–312 (with 1 mM ALA) 312 (with 1 mM ALA) |
HeLa A431 |
[94] |
| Apoptosis | Approx. 0.84 ^ | 100 | AsPC1 | [95] |
| Apoptosis | 0.84 | 200 | HL-60 | [96] |
^ The precise dose was not mentioned but irradiation parameters were the same as described in [80]; δ-aminolevulinic acid (ALA).