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. 2022 Jun 25;14(13):3115. doi: 10.3390/cancers14133115

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mesenchymal cells can grow tumors and revert to an epithelial state. (A) Schematic representation of experimental design. (B) Representative pictures and H&E staining of the mouse brain. Pie charts show the percentage of BCBM tumors formed after intracranial injection of approximately 2000 E-cad^LO tumor cells compared to the purity control group. n = 4 mice per group. (C) Representative images of immunofluorescent staining (left and middle panels) of H2B-Dendra2 (green) and the endogenous E-cad-mCFP (turquoise) reporter in tumors formed after intracranial injection of E-cad^LO tumor cells. The expression of E-cadherin was confirmed using immunohistochemistry with an E-cadherin antibody (right panel). n = 3 mice.