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(a) Age-adjusted incidence rate (per 100,000); (b) age-adjusted mortality rate (per 100,000) of patients with extrahepatic cholangiocarcinoma. Kaplan–Meier curves of patients with extrahepatic cholangiocarcinoma: (c) Male vs. female patients (median OS for m and f, 10.1 and 7.1 months, respectively, p = 0.001); (d) comparison of OS with former time periods (median OS for 1990–1999, 4.4 months; 2000–2009, 6.3 months; and 2010–2018, 9.1 months; p < 0.001).
