Figure 3.

CDK4/CDK6 inhibitors induce growth arrest in primary neoplastic MC. Primary neoplastic MC obtained from one patient with ISM and three patients with AdvSM (as indicated) were incubated in control medium (0 nM) or medium containing various concentrations of palbociclib, ribociclib, or abemaciclib as indicated, at 37 °C for 48 h. Thereafter, ³H-thymidine uptake was measured. Results are expressed as percentage of control and represent the mean ± S.D from triplicates. Statistical significance was reached in all experiments, as analyzed by ANOVA and post-testing by Dunnett test (Supplementary Materials, Table S8). The patient’s number refers to Table 1. Abbreviations: SM, systemic mastocytosis; ISM, indolent SM; ASM, aggressive SM; MCL, mast cell leukemia, AML, acute myeloid leukemia; MDS, myelodysplastic syndrome; MPN, myeloproliferative neoplasm; CMML, chronic monomyelocytic leukemia; u, unspecified; µM, micromolar.