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. 2022 Jun 28;14(13):3164. doi: 10.3390/cancers14133164

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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GPR56 expression is elevated on ovarian cancer TILs compared to healthy peripheral blood lymphocytes and associates with an effector memory phenotype. (A,B) GPR56 expression analyzed on CD3, CD4 and CD8 fractions of healthy T cells and ovarian cancer TILs (n > 10) by flow cytometry. A 2way ANOVA was performed to determine significance. (C) Different T cell developmental subsets (naïve, central memory, effector memory and effector memory RA (based on CD45RO and CCR7 expression) within the GPR56-positive CD4 and CD8 T cell fractions of peripheral blood lymphocytes and ovarian cancer TILs (n > 5). (D) Expression levels of effector (CD69 and CD25) and co-stimulatory (OX40 and 4-1BB) molecules within the GPR56-positive CD3, CD4 and CD8 T cell fractions of ovarian cancer TILs from 3 different donors. Individual donor variations between the GPR56+ and GPR56- fractions are displayed. Across the figure, t-test values: *** = p < 0.001, **** = p < 0.0001, all error bars in the figure represent SD.