Table 3.
Performance of the candidate prognostic protein signatures for Index I.
| Signature | Discovery Cohort (n = 243) | Replication Cohort (n = 120) | Replication Cohort When Adding Age to the Model (n = 120) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | BP Sens |
BP Spec |
PPV | NPV | AUC | BP Sens |
BP Spec |
PPV | NPV | AUC | BP Sens |
BP Spec |
PPV | NPV | DeLong Test p Value | |
| Values with 95% confidence intervals in parentheses | ||||||||||||||||
| 1 | 0.90( 0.75–1) |
0.90 (0.75–1) |
0.90 (0.60–1) |
0.94 (0.83–1) |
0.81 (0.66–1) |
0.72 (0.53–0.92) |
0.61 (0.33–0.88) |
0.88 (0.66–1) |
0.91 (0.81–1) |
0.53 (0.42–0.81) |
0.72 (0.53–0.92) |
0.61 (0.33–0.88) |
0.88 (0.66–1) |
0.91 (0.81–1) |
0.53 (0.42–0.81) |
1 |
| 2 | 0.93 (0.80–1) |
1 (1–1) |
0.90 (0.70–1) |
0.95 (0.86–1) |
1 (1–1) |
0.75 (0.56–0.94) |
0.66 (0.38–0.94) |
0.88 (0.55–1) |
0.92 (0.78–1) |
0.57 (0.42–0.87) |
0.75 (0.56–0.94) |
0.66 (0.38–0.94) |
0.88 (0.55–1) |
0.92 (0.80–1) |
0.57 (0.43–0.88) |
1 |
| 3 | 0.90 (0.76–1) |
1 (0.75–1) |
0.80 (0.60–1) |
0.90 (0.83–1) |
1 (0.66–1) |
0.77 (0.57–0.96) |
0.77 (0.50–0.94) |
0.77 (0.55–1) |
0.87 (0.80–1) |
0.63 (0.46–0.90) |
0.77 (0.59–0.96) |
0.77 (0.44–0.94) |
0.77 (0.66–1) |
0.87 (0.80–1) |
0.63 (0.46–0.88) |
0.692 |
| 4 | 0.94 (0.83–1) |
1 (1–1) |
0.90 (0.70–1) |
0.95 (0.86–1) |
1 (1–1) |
0.80 (0.62–0.98) |
0.72 (0.50–1) |
0.88 (0.55–1) |
0.92 (0.80–1) |
0.61 (0.46–1) |
0.80 (0.62–0.98) |
0.83 (0.55–1) |
0.77 (0.55–1) |
0.88 (0.80–1) |
0.70 (0.5–1) |
1 |
| 5 | 0.95 (0.84–1) |
1 (1–1) |
0.90 (0.70–1) |
0.95 (0.86–1) |
1 (1–1) |
0.81 (0.64–0.98) |
0.77 (0.49–1) |
0.77 (0.55–1) |
0.87 (0.78–1) |
0.63 (0.47–1) |
0.80 (0.62–0.98) |
0.83 (0.50–1) |
0.77 (0.55–1) |
0.88 (0.80–1) |
0.70 (0.47–1) |
0.624 |
| 6 | 0.95 (0.84–1) |
1 (1–1) |
0.90 (0.70–1) |
0.95 (0.86–1) |
1 (1–1) |
0.81 (0.64–0.98) |
0.77 (0.38–1) |
0.77 (0.44–1) |
0.87 (0.78–1) |
0.63 (0.45–1) |
0.80 (0.63–0.98) |
0.83 (0.44–1) |
0.77 (0.55–1) |
0.88 (0.78–1) |
0.70 (0.46–1) |
0.829 |
| 7 |
0.99
(0.98–1) |
0.95
(0.90–1) |
1
(0.90–1) |
1
(0.95–1) |
0.90
(0.83–1) |
0.89
(0.74–1) |
1
(0.72–1) |
0.77
(0.55–1) |
0.90
(0.81–1) |
1
(0.61–1) |
0.88
(0.73–1) |
0.88
(0.61–1) |
0.77
(0.55–1) |
0.88 c (0.80–1) |
0.77
(0.53–1) |
0.570 |
| 8 | 0.95 (0.88–1) |
1 (0.70–1) |
0.80 (0.70–1) |
0.90 (0.86–1) |
1 (0.62–1) |
0.80 (0.64–0.97) |
0.66 (0.44–1) |
0.88 (0.55–1) |
0.92 (0.80–1) |
0.57 (0.46–1) |
0.77 (0.59–0.95) |
0.72 (0.44–0.94) |
0.88 (0.66–1) |
0.92 (0.84–1) |
0.61 (0.47–0.88) |
0.533 |
| 9 | 0.98 (0.95–1) |
1 (0.80–1) |
0.90 (0.80–1) |
0.95 (0.90–1) |
1 (0.71–1) |
0.77 (0.60–0.95) |
0.61 (0.38–1) |
0.88 (0.55–1) |
0.91 (0.81–1) |
0.53 (0.45–1) |
0.77 (0.6–0.95) |
0.55 (0.38–0.94) |
1 (0.66–1) |
1 (0.83–1) |
0.52 (0.45–0.87) |
1 |
| 10 | 0.96 (0.89–1) |
0.95 (0.75–1) |
0.90 (0.80–1) |
0.95 (0.90–1) |
0.90 (0.66–1) |
0.80 (0.64–0.97) |
0.72 (0.44–1) |
0.88 (0.66–1) |
0.92 (0.84–1) |
0.61 (0.47–1) |
0.80 (0.64–0.97) |
0.72 (0.49–0.94) |
0.88 (0.66–1) |
0.92 (0.84–1) |
0.61 (0.47–0.9) |
1 |
| 11 | 0.93 (0.83–1) |
0.95 (0.65–1) |
0.80 (0.80–1) |
0.90 (0.90–1) |
0.88 (0.58–1) |
0.83 (0.67–1) |
1 (0.44–1) |
0.55 (0.44–1) |
0.81 (0.78–1) |
1 (0.47–1) |
0.80 (0.62–0.98) |
0.77 (0.38–1) |
0.77 (0.55–1) |
0.87 (0.78–1) |
0.63 (0.45–1) |
0.347 |