Table 4.
Comparison of protein levels at different timepoints vs. OS in univariate and multivariate analyses.
| Protein | Baseline Sample | Before Second Treatment | Before First CT Scan (3 Months) | |||
|---|---|---|---|---|---|---|
| Univariate Analysis, HR, p Value |
Multivariate Analysis, HR, p Value |
Univariate Analysis, HR, p Value |
Multivariate Analysis, HR, p Value |
Univariate Analysis, HR, p Value |
Multivariate Analysis, HR, p Value |
|
| CSF-1 | 1.85, p < 0.0001 | 1.79, p < 0.0001 | 1.33, p = 0.0464 | 1.35, p = 0.0502 | 1.57, p = 0.004 | 1.40, p = 0.043 |
| CXCL13 | 1.44, p = 0.0007 | 1.30, p = 0.0234 | 1.42, p = 0.0148 | 1.33, p = 0.0663 | 1.66, p = 0.001 | 1.49, p = 0.02 |
| IL-6 | 2.16, p < 0.0001 | 2.08, p < 0.0001 | 1.63, p = 0.0007 | 1.57, p = 0.0030 | 1.82, p = 0.0001 | 1.62, p = 0.0045 |
| TNFRSF12A | 1.67, p < 0.0001 | 1.57, p < 0.0001 | 1.72, p = 0.0002 | 1.68, p = 0.0008 | 1.85, p < 0.0001 | 1.79, p = 0.0004 |
In the multivariate analyses, the protein levels are combined with age, stage, baseline performance status, baseline CA19-9, and type of palliative chemotherapy.