Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 27;14(13):3148. doi: 10.3390/cancers14133148

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic representation of the human TOP2α gene, TOP2α/160 mRNA, and TOP2α/160 isoform. (A) The human TOP2α gene comprises of 35 exons and spans ~35 kb. (B) When Intron 33 IPA occurs, the predominate TOP2α mRNA transcript is 4550 nucleotides long. (C) This mRNA encodes a TOP2α isoform of 1436 aa, denoted TOP2α/160. The truncated TOP2α/160 isoform is missing the nuclear localization signal (NLS 1454-1497) and is found predominantly in the cytoplasm. Therefore, the number of TOP2α/170 DNA covalent cleavage complexes are reduced and drug resistance occurs.