Table 4.

Summary of non-omics data that appear in the reviewed papers. Methods used to obtain them and the variables containing the pertinent information to build the models are listed along with the bibliographical reference.

Type of Molecular Data	Methods	Variables	Used by
IHC data	Immuno- histochemical staining	Presence/absence of proteins in tumour tissue (e.g., ER, PR, Ki-67)	[72,74,75,81,84,89,98,100]
		Percentage of protein expression in tumour tissue (e.g., ER, Ki-67, etc.)	[86]
		Over-expression of proteins in tumour tissue (e.g., HER-2)	[79]
Genetic data	PCR-based methods	The molecular subtype of cancer (luminal A, luminal B, HER-2 positive luminal B, non-luminal HER-2 positive, triple-negative)	[74]
		Somatic point mutations (e.g., IDH R132H mutation)	[87]
		Mutational status of genes	[71,99]

Abbreviations: IHC, Immunohistochemistry; PCR, Polymerase Chain Reaction; ER, estrogen receptors; PR, progesterone receptors; HER-2, Human Epidermal Growth Factor receptor 2; IDH, Isocitrate Dehydrogenase gene.