. 2022 Jun 22;14(13):3065. doi: 10.3390/cancers14133065

Table 4.

MBSS Part A and Part B scores: classification performance and sub-group analysis.

Milan Biometric Surgical Score for Intracranial Meningiomas (MBSS-Men Score; Part A)
ITEM	MEASURE	SCORE VALUE
ASA Score	1–2	0
	>2	3
Frailty Index	<0.10	0	Multivariate regression analysis		Odd Ratio (OD)	Standard Error (S.E.)	p Value	95% C.I.
	0.10–0.20	2	Multivariate regression analysis		Odd Ratio (OD)	Standard Error (S.E.)	p Value	95% C.I.
	>0.20	3	Post-operative prognostic Score	MBSS (Part A)	2.611	0.293	0.001	1.469–4.640
Skull base location	Yes	1	Post-operative prognostic Score	Constant	0	3.056	0
	No	0
Infratentorial location	Yes	3	*AUR-ROC analysis*		Area (AUC)	Std. Error (S.E.)	p Value	95% C.I.
	No	0			Area (AUC)	Std. Error (S.E.)	p Value	95% C.I.
Diameter > 2.5 cm	>25 mm	3		Overall population	0.956	0.034	0	0.890–1.022
	<25 mm	0		Age 18–65 years	0.878	0.042	0	0.794–0.961
Tumor-Brain cleft on T2WI	Absent	2		Age > 65 years	0.981	0.017	0	0.948–1.013
	Present	0		Age > 70 years	0.973	0.024	0	0.926–1.020
	RANGE	0–15		Age > 80 years	0.911	0.074	0	0.765–1.057
Milan Biometric Surgical Score for intracranial meningiomas (MBSS-Men Score; Part B)
Frailty Index	<0.10	0
	0.10–0.20	1
	>0.20	3
Infratentorial location	Yes	2
	No	0	*Multivariate regression analysis*		Odd Ratio (OD)	Standard Error (S.E.)	p Value	95% C.I.
Diameter > 2.5 cm	>25 mm	1	*Multivariate regression analysis*		Odd Ratio (OD)	Standard Error (S.E.)	p Value	95% C.I.
	<25 mm	0	Follow-up prognostic Score	MBSS (Part B)	2.961	0.203	0	1.988–4.411
Severe peritumoral edema	Yes	1	Follow-up prognostic Score	Constant	0.004	0.876	0
	No	0
Sinus Invasion	Yes	1	*AUR-ROC analysis*		Area (AUC)	Std. Error (S.E.)	p Value	95% C.I.
	No	0			Area (AUC)	Std. Error (S.E.)	p Value	95% C.I.
DWI hyperintensity	Present	1		Overall population	0.877	0.033	0	0.811–0.942
	Absent	0		Age 18–65 years	0.901	0.04	0	0.823–0.978
Tumor-Brain cleft in T2WI	Absent	1		Age > 65 years	0.854	0.054	0	0.749–0.959
	Present	0		Age > 70 years	0.85	0.055	0	0.741–0.959
	RANGE	0–10		Age > 80 years	0.861	0.088	0	0.689–1.033

(Left) The parameters independently associated with the outcomes investigated were selected and filled into a newly designed prognostic score. The Milan Biometric Surgical Score (MBSS) was split in two subparts: Part A comprehended all of the significant predictors of early post-operative functional outcome, while Part B comprehended those predictors affecting long-term functional outcome and quality of life. A chart for MBSS was designed and each parameter was given a value according to its odds ratio on a multivariable regression analysis. MBSS-Part A had a range from 0 to 15. MBSS-Part B had a range from 0 to 10. (Right) The current table reports the classification analysis of MBSS Part A and Part B in predicting early post-operative functional deterioration and long-term unfavourable outcome at follow-up, respectively. Each sub-score was tested first on the overall population and then on the age-specific subgroups.