Table 1.
NSGS mice engrafted with human umbilical cord blood develop pancytopenia.
| NSGS | NSG | NSGS Hu | NSG Hu | ||||
|---|---|---|---|---|---|---|---|
| Week | Busulfan Concentration (mg/kg) | ||||||
| 0 | 12.5 | 25 | 25 | ||||
| RBC (M/μL) | 8.0 ± 0.32 | 10 | 6.28 ± 0.12 | 4.75 ± 1.78 | 4.70 ± 0.71 | 8.12 ± 0.30 | |
| 8.8 ± 0.54 | 14 | 4.74 ± 0.81 | 3.99 ± 0.53 | 3.84 ± 0.76 | 7.22 ± 0.34 | ||
| 18 | 3.04 ± 1.98 | 2.31 ± 0.38 | 3.45 ± 0.06 | 5.92 ± 0.99 | |||
|
HGB (g/dl) |
13.48 ± 0.51 | 10 | 12.1 ± 0.4 | 9.30 ± 3.38 | 9.67 ± 1.12 | 13.50 ± 0.5 | |
| 13.96 ± 0.94 | 14 | 9.83 ± 1.55 | 8.50 ± 0.82 | 8.3 ± 1.01 | 12.72 ± 0.63 | ||
| 18 | 6.73 ± 4.05 | 5.40 ± 0.99 | 7.75 ± 0.21 | 10.74 ± 1.85 | |||
|
Platelets (K/μL) |
1007.4 ± 69.2 | 10 | 635.3 ± 41.2 | 406.3 ± 174.2 | 296 ± 103.5 | 508.3 ± 52.8 | |
| 1093.4 ± 94.6 | 14 | 550.0 ± 225.4 | 280.0 ±1 33.4 | 315.0 ± 109.3 | 619.0 ± 104.7 | ||
| 18 | 228.0 ± 143.4 | 174.0 ± 144.3 | 222.0 ± 18.4 | 544.2 ± 114.0 | |||
RBC, red blood cells; HGB, hemoglobin.