Impact of the BM MRD status Panels (A,D,G,J), the percentage of BM endothelial cells Panels (B,E,H,K) within the whole BM stromal cell compartment at day +78 or both parameters Panels (C,F,I,L) on disease free survival (DFS) of BCP-ALL patients. Panels (A–C) show data for the discovery patient cohort, while (D–F,J–L) panels display survival curves for the validation cohorts of childhood and adult BCP-ALL patients, respectively. DFS curves of all childhood BCP-ALL cases (the discovery plus the validation cohorts) are shown in panels (G–I). Statistical significance was set at p < 0.05 (log rank test).