Table 2.
Univariate and multivariate analysis of prognostic factors for disease-free survival (DFS) of children diagnosed with BCP-ALL included in the discovery cohort (n = 116).
| Univariate Analysis | Multivariate Analysis | Multivariate Analysis * | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median DFS (Years) | HR | 95th CI | p-Value | HR | 95th CI | p-Value | HR | 95th CI | p-Value | |
| CHILDHOOD BCP-ALL | ||||||||||
| Discovery Cohort | ||||||||||
| Age at diagnosis | ||||||||||
| ≥1 to <10 years | 5.60 | 1 | ||||||||
| <1 or ≥10 years | 4.67 | 2.62 | (1.14–6.03) | 0.024 | ||||||
| Genetic Abnormalities | ||||||||||
| Favorable | 5.95 | 1 | ||||||||
| Adverse | 3.01 | 3.30 | (1.02–10.65) | 0.046 | ||||||
| MRD Status | ||||||||||
| Day +33 MRD− | 5.88 | 1 | ||||||||
| MRD+ | 5.40 | 2.62 | (1.04–6.60) | 0.041 | ||||||
| Day +78 MRD− | 5.92 | 1 | 1 | |||||||
| MRD+ | 3.30 | 3.32 | (1.13–9.73) | 0.029 | 3.28 | (1.12–9.66) | 0.031 | |||
| % Stromal cells | ||||||||||
| Day +33 ≤0.21% | 6.02 | 1 | ||||||||
| >0.21% | 3.85 | 3.04 | (1.20–7.70) | 0.019 | ||||||
| % Endothelial cells (EC) | ||||||||||
| Day +78 ≤32% |
6.01 |
1 |
1 | |||||||
| >32% | 3.97 | 2.27 | (1.01–5.10) | 0.048 | 2.50 | (1–9.66) | 0.05 | |||
| MRD Status and %EC | ||||||||||
| Day +78 | ||||||||||
| MRD− and %EC ≤ 32% | 6.09 | 1 | 0.001 | 1 | 0.001 | |||||
| MRD+ or %EC ≤ 32% MRD− or %EC > 32% |
4.13 | 2.12 | (0.92–4.86) | 2.12 | (0.92–4.86) | |||||
| MRD+ and %EC > 32% | 1.56 | 9.63 | (2.14–43.32) | 9.63 | (2.14–43.32) | |||||
* Multivariate analysis including the contribution of MRD status and %EC at day +78. Abbreviations: CI: confidence interval; HR: hazard ratio; MRD: minimal residual disease; EC: endothelial cells.