Figure 2.

Strategy for applying canine induced pluripotent stem cells (ciPSCs) as a bidirectional model for genetic cardiomyopathies. Patient-specific ciPSC-cardiomyocytes can be used for both drug screenings and disease modeling. With the additional application of genetic engineering, healthy, patient-derived ciPSCs can be created and used for more advanced therapeutic modeling purposes. Advances made in the canine and human fields can be translated across species boundaries. Created with BioRender.com.