Table 1.
Comparison of mutated genes involved in the development of DCM in humans and dogs. Overlap is found in genes that encode for cytoskeleton, sarcomeric, and other unclassified proteins. Bold: overlapping genes between species.
| Canine | Human [60,61] | ||
|---|---|---|---|
| Sarcomeric | TTN (Dobbermann [45]) |
TTN
MYH6 MYBPC3 TNNT1 MYL3 MYL2 |
ACTC1
MYH7 TNNC1 TPM1 TNNI3 TNNT2 |
| Z-disc |
MYPN
ANKRD1 CSRP3 ACTN2 |
TCAP
NEBL |
|
| Cytoskeleton |
DMD (German short-haired pointer [1]) ARHGAP8 (Irish wolfhound [52]) |
DMD VCL DES ILK LDB3 LAM4 CRYAB |
FLNC
SGCD SGCB SGCA SGCG PDLIM3 |
| Nuclear envelope |
LMNA
TMPO EMD |
SYNE1
SYNE2 |
|
| Sarcoplasmic reticulum |
PLN (Welsh springer spaniel [53]) PDE3B (Irish wolfhound [52]) |
PLN | |
| RNA binding | RBM20 (Schnauzer [63]) | RBM20 | |
| Other |
PDK4 (Dobbermann [42]) STRN (Boxer [40]) FSTL5 (Irish wolfhound [52]) |
SCN5A
BAG3 DSC2 DSP PSEN1 |
ABCC9
DSG2 EYA4 TAZ PSEN2 |