Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 1;14(13):3252. doi: 10.3390/cancers14133252

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Four frequently mutated genes in CRC (SMAD4, FBXW7, ARID1A, or BMPR2) are involved in the TGF-β/BMP pathway. (A) Scheme of the TGF-β/BMP pathway with four frequently mutated genes in CRC (circled): SMAD4 = mothers against decapentaplegic homolog 4, FBXW7 = F-box/WD repeat-containing protein 7, ARID1A = AT-rich interactive domain-containing protein 1A, BMPR2 = Bone morphogenetic protein receptor type II. (B) Frequency of SFAB (SMAD4, FBXW7, ARID1A, or BMPR2) in CRC patients (TCGA = The Cancer Genome Atlas, PanCancer Atlas colorectal adenocarcinomas (n = 594) (https://www.cbioportal.org, accessed on 18 August 2021)). (C) Frequency of SFAB in CRC PDOs (n = 62). (See also Table S2).