Figure 2.

Challenges in GBM treatment. GBM has remarkable features that make it so malignant and difficult to treat. Infiltrative cells, immune evasion, stem cells capable of repopulating the tumor mass after treatment and exchange of soluble factors and vesicles among the tumor cells, form a complex microenvironment that, together with the blood–brain barrier that hinders the entry of molecules into the brain tissue reducing the pharmacological options for the treatment of this tumor, contributes to the difficulty in the therapeutic advance of GBM.