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. 2022 Jul 5;14(13):3280. doi: 10.3390/cancers14133280

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CircRNA transcriptomic profile according to mutational data of TNBC patients. (A) Principal component analysis showing overall similarity in expression data between Wildtype, Wildtype with BRCA1 hypermethylated, and BRCA1 mutated patients; (B) differential expression analysis showed significant results when comparing Wildtype and BRCA1 mutated patients, in which it was possible to observe nine differentially expressed circRNAs, being one downregulated (hsa_circ_0001821) and eight upregulated (hsa_circ_0001550, circ_0001178, circ_0006376, circ_0023942, circ_0001314, circ_0001789, and circ_0000343); (C) Reactome enrichment of the RBPs predicted to interact with these circRNAs revealed similar pathways to the ones enriched in the TNBC vs. adjacent tissue comparison.