Table 1.
Clinical characteristics and outcome of TNBC patients.
| Clinical Characteristics | Wildtype | Wildtype, BRCA Hypermethylated | BRCA1 Mutation | |||
|---|---|---|---|---|---|---|
| n = 18 | n = 10 | p-Value * | n = 9 | p-Value * | ||
| Age of onset, mean (SD) | 41.8 (6.1) | 38.5 (7.6) | 0.3 | 36.5 (5.6) | 0.16 | |
| nº (%) | nº (%) | nº (%) | ||||
| TNM classification, T | T1 | 3 (16.7) | - | 0.11 | 1 (11.1) | 0.94 |
| T2 | 8 (44.4) | 9 (90) | 5 (55.6) | |||
| T3 | 3 (16.7) | 1 (10) | 2 (22.2) | |||
| T4 | 4 (22.2) | - | 1 (11.1) | |||
| TNM classification, N | N0 | 5 (27.8) | 8 (80) | 0.054 | 5 (55.6) | 0.59 |
| N1 | 7 (38.9) | 2 (20) | 3 (33.3) | |||
| N2 | 4 (22.2) | 1 (11.1) | ||||
| N3 | 2 (11.1) | - | ||||
| TNM classification, M | M0 | 11 (61.1) | 8 (80) | 0.41 | 4 (44.4) | 0.06 |
| M1 | 7 (38.9) | 2 (20) | 2 (22.2) | |||
| Mx | - | - | 3 (33.3) | |||
| Tumor stage | I | 2 (11.1) | - | 0.07 | 1 (11.1) | 0.45 |
| II | 7 (38.9) | 9 (90) | 5 (55.6) | |||
| III | 7 (38.9) | 1 (10) | 1 (11.1) | |||
| IV | 2 (11.1) | - | - | |||
| Tumor grade | 2 | 4 (22.2) | - | 0.26 | - | 0.056 |
| 3 | 14 (77.8) | 10 (100) | 7 (77.8) | |||
| Chemotherapy | No | 11 (61.1) | 8 (80) | 0.5 | 6 (66.7) | 0.65 |
| Yes | 4 (22.2) | 2 (20) | 3 (33.3) | |||
| TP53 mutation | No | 4 (22.2) | - | 0.13 | 4 (44.4) | 1 |
| Yes | 12 (66.7) | 6 (60) | 5 (55.6) | |||
| Family history | No | 10 (55.6) | 5 (50) | 0.87 | 2 (22.2) | 0.001 |
| Yes | 2 (11.1) | 2 (20) | 7 (77.8) | |||
| Outcome | ||||||
| Relapse or metastasis | No | 11 (61.1) | 5 (50) | 0.69 | 7 (77.8) | 1 |
| Yes | 7 (38.9) | 5 (50) | 2 (22.2) | |||
| Death | No | 13 (72.2) | 7 (70) | 1 | 7 (77.8) | 1 |
| Yes | 5 (27.8) | 3 (30) | 2 (22.2) | |||
SD: standard deviation; TP53: tumor protein p53. * p-values were calculated using Fisher’s Exact test for categorical variables and a pairwise t-test (with FDR correction after multiple comparisons) for continuous variables (age). Statistically significant values (p < 0.05) are highlighted in bold.