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. 2022 Jun 25;11(13):2026. doi: 10.3390/cells11132026

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A scheme of the epidermis and dermis in normal skin (A), psoriasis (B) and fibrosis (C). Morphologically, psoriatic inflammation is characterized by epidermal hyperproliferation and thickening (acanthosis), an increased infiltration of immune cells into the dermis and epidermis, alterations in the composition of the dermal ECM, and damage to the BM. Fibrotic skin is characterized by excessive ECM deposition by the dermal myofibroblasts and an increased presence of immune cells in the dermis. Figure created in Biorender.com 14.06.2022.