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The loss-of-function of KDM5C promotes clear cell renal cell carcinoma (ccRCC). The loss-of-function of KDM5C increases genomic instability in ccRCC by heterochromatin dysregulation through the upregulation of non-coding (nc)RNAs. KDM5C deficiency also promotes angiogenesis. In VHL-deficient ccRCC cells, KDM5C deficiency promotes tumor growth by suppressing the tumor suppressor ISGF3, which is induced by HIF.
