Table 1.

Representative binding partners of KDM5 proteins.

Partner Proteins	KDM5 Isoforms	Functions	References
HDAC1/HDAC2	KDM5A/KDM5B/KDM5C	Transcriptional repression	[10,20,30,33,34,35,36]
LSD1	KDM5B	Transcriptional repression	[30]
SIN3B	KDM5A	Transcriptional repression	[33,35,37]
EMSY	KDM5A/KDM5B	Transcriptional repression	[33,35,38]
EZH2/SUZ12	KDM5A/KDM5B	Transcriptional repression	[39,40]
G9a	KDM5A/KDM5C	Transcriptional repression	[10,41]
REST	KDM5C	Transcriptional repression	[10]
RBP-J	KDM5A	Transcriptional repression	[28]
pRb	KDM5A	Transcriptional repression	[42,43]
KLF10	KDM5B	Transcriptional repression	[29]
SETDB1	KDM5B	Transcriptional repression	[44]
ZMYND8	KDM5A/KDM5C/KDM5D	Transcriptional repression or activation	[33,35,36,45,46]
MYC	KDM5A/KDM5B	Transcriptional repression or activation	[31,35,47]
CCNT2/CDK9	KDM5A	Transcriptional activation	[35]
CCNT1/CDK9	KDM5C	Transcriptional activation	[36]
ER	KDM5A/KDM5B/KDM5C	Transcriptional activation	[36,48,49]
RAR	KDM5A/KDM5B	Transcriptional repression or activation	[40,48]
AR	KDM5B/KDM5D	Transcriptional repression or activation	[50,51]
CLOCK/BMAL1	KDM5A	Transcriptional activation	[52]

ER: estrogen receptor; RAR: retinoic acid receptor; AR: androgen receptor.