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. 2022 Jun 29;11(13):2064. doi: 10.3390/cells11132064

Figure 3.

Figure 3

Mutant TP53 expression influences intracellular iron availability and the activity on iron-containing enzymes. (A) Total intracellular iron in cells expressing distinct TP53 mutation types under control conditions and following treatment with 50 µM DFO for 48 h. (B) Cytosolic (C) and mitochondrial aconitase activity in cells expressing distinct TP53 subtypes. (D) Cytosolic aconitase activity is directly correlated to levels of intracellular iron under control conditions. * Denotes statistical difference from respective control, p < 0.05. Superscripts (a, b, c) denote statistical difference between TP53 subtypes. Subtypes with the same superscripts are not statistically different. Error bars indicate SEM.