Table 1.
DEGs in the 3D spheroid system compared with the 2D culture *.
| Gene Symbol | Gene Name | Biological Function | Fold-Change | p Value ** |
|---|---|---|---|---|
| OXTR | Oxytocin receptor | Cell-surface-receptor signalling pathway; oxidative stress | 24.82 | 0.0002 |
| COL11A1 | Collagen alpha-1 (XI) chain | Extracellular matrix binding | 21.67 | 0.003 |
| SSTR1 | Somatostatin receptor type 1 | Expressed during anagen; HF immune system | 21.03 | 0.001 |
| NEDD9 | Enhancer of filamentation 1 | Cell adhesion; hair placode signature genes | 18.48 | 0.004 |
| HAPLN1 | Hyaluronan and proteoglycan link protein 1 | Cell adhesion; cell–cell communication | 14.06 | 0.005 |
| IL8 | Interleukin-8 | Immune response; inflammation | −179.99 | 0.004 |
| TNFAIP6 | Tumor necrosis factor-inducible gene 6 protein | TNF-α signalling; inflammation | −32 | 0.001 |
| RANBP3L | Ran-binding protein 3-like | Termination of BMP signalling; inhibition of mesenchymal stem cell differentiation | −31.18 | 0.003 |
| GDF15 | Growth/differentiation factor 15 | Stress response cytokine, expression increases with inflammation and injury | −25.96 | 0.045 |
* Gene functions were obtained from Mouse Genome Informatics (MGI). ** ANOVA was performed to assess the level of significance between groups. The gene expression was considered significant when the fold change was ≥2-fold (control vs. TCQA).