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. 2022 Jul 5;11(13):1984. doi: 10.3390/foods11131984

Figure 2.

Figure 2

Grape powder supplementation of a high-fat diet affects temporal weight loss and increases the lifespan of C57BL/6J mice. (A) At 14-weeks-of-age, mice were divided into two groups (n = 100 per group), and diet was changed from the STD to either the high-fat diet (HFD) or the high-fat diet supplemented with 5% grape powder (HFD5GP) for the remainder of their lifespan. Body weight was recorded every two weeks and recorded as mean ± SD. (B) Kaplan-Meier plot showing the survival of mice provided with the HFD or the HFD5GP. Survival was enhanced with the group provided with the HFD5GP (p = 0.036; log-rank test). The hazard ratio of the HFD group was 1.397 (95% CI, 0.99–1.96), whereas the hazard ratio for the HFD5GP group was 0.715 (95% CI, 0.507–1.009). (C) Correlation plots showing the age at highest body weight versus lifespan for individual mice (upper panels), and the highest body weight attained by individual mice versus lifespan (lower panels).