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The effect of S1PR1 internalization in the lymph nodes and how regulates the gradient of lymphocytes between SLO/blood. This scheme shows the sequestration of naive T cells and CCR7 expressing central memory T cells due to the inability to response to the altered lymphocyte gradient between SLO/blood. S1PR = Sphingosine1-phosphate receptor; TN = naÏve T cells; TCM = central memory T cells; SLO = secondary lymphatic organs.
