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. 2022 Jul 2;14(13):3254. doi: 10.3390/cancers14133254

Figure 2.

Figure 2

Schematic representation of the functional domains of BRCA1 and BRCA2 proteins. BRCA1 protein consists of 1863 amino acids and BRCA2 protein of 3418 amino acids. The N-terminal region of BRCA1 contains a RING domain that associates with the BARD1 protein. The central region of the protein contains two nuclear localization signals (NLS) and the C-terminal of BRCA1 contains a coiled-coil domain that associates with PALB2 and two BRCT domains that mediate interaction with different proteins. Regarding BRCA2, it binds to PALB2 through the N-terminal region and contains 8 BRC repeats, in the central region, responsible for its association with the RAD51 protein. In the C-terminal region, it contains a DNA-binding domain, consisting of a helical domain, a tower domain (T) and three oligonucleotide binding (OB) domains, which facilitates the binding of BRCA2 to DNA lesions. Furthermore, the carboxy terminal contains two NLS domains and a TR2 domain. Created with BioRender.com.