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Multilayered levels of pancreatic ductal adenocarcinoma (PDAC) stromal heterogeneity. PDAC desmoplastic stroma is highly heterogenous between patients and even in a tumor at multilayered levels. Abbreviations: CAF, cancer-associated fibroblast; CTL, cytotoxic T cell; ECM, extracellular matrix; iCAF, inflammatory cancer-associated fibroblast; MDSC, myeloid-derived suppressor cell; myCAF, myofibroblast cancer-associated fibroblast; TME, tumor microenvironment; Treg, regulatory T cell.
