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Structural models for the Pex1/Pex6 peroxisomal tethers: S. cerevisiae Pex15, H. sapiens PEX26, and A. thalania PEX26, based AlphaFold2 multimer predictions. Pathogenic missense mutations in PEX26 (D43H, L44P, L45P, G89R, R98W, P117L, and P118R) are colored in blue (Leiden Open Variation Database 3.0, [199]). Predictions for transmembrane domains are from the highest scores from TMHMM-2.0 [200]. Helical wheels generated in Heliquest [201], letters indicate predicted protein sequence.
